Dictionary

All 67 biomarkers at mybody x at a glance

Leere Laborröhrchen mit hellblauen Deckeln in einem hellen Holzständer

Search, filter, and discover all markers - from micronutrients and hormones to cardiovascular health.

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67 Markers

Strictly speaking, vitamin D is a hormone that the body produces in the skin when exposed to UV-B radiation. The storage form, 25-OH vitamin D3, is measured because it reliably reflects vitamin D status over several weeks. Vitamin D regulates calcium absorption from the gut and also affects muscles and the immune system.

Test requirementsNo special requirements
Reference rangeadequate from 30 ng/ml (deficiency below 20 ng/ml)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

In Germany, sunlight from October to March is insufficient to produce enough vitamin D. Deficiencies are therefore widespread and usually go unnoticed because the symptoms - fatigue, muscle weakness, and susceptibility to infections - are nonspecific.

High level

Very high levels are practically only caused by taking excessive doses of supplements and can be harmful by raising calcium levels. It is not possible to overdose through sunlight alone.

Low level

Low levels increase the risk of bone loss, muscle weakness, and susceptibility to infections. At-risk groups include older adults, people with dark skin, shift workers, and anyone who spends little time outdoors.

Frequently asked questions

When should vitamin D levels be tested?
A test is most informative at the end of winter, in February or March, when stores are at their lowest.

How long does it take for levels to improve?
With regular use, levels rise over about eight to twelve weeks. A follow-up test is advisable no sooner than three months later.

Is summer sun enough?
For people with fair skin, 10 to 20 minutes of midday sun on the face and forearms is often enough in summer. In winter, the sun is too low in Germany for significant production in the body.

Alanine connects muscle and liver metabolism. During physical exertion or fasting, muscles release nitrogen in the form of alanine. The liver uses it to produce new glucose - the so-called glucose-alanine cycle, which keeps blood sugar stable even during fasting.

Test requirementsFasting, at least 12 hours
Reference range200–580 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Alanine provides insight into protein and energy metabolism and how much the body draws on muscle protein for energy.

High level

High levels are found with high protein intake, insulin resistance, and liver disease.

Low level

Low levels occur in cases of severe protein deficiency.

Frequently asked questions

What is the glucose-alanine cycle?
A cycle between muscle and liver: The muscle provides alanine, which the liver converts into glucose and sends back. This keeps blood sugar stable even during prolonged fasting.

Related markers

Albumin is the most abundant protein in the blood and is produced by the liver. It keeps water in the blood vessels and transports hormones, calcium, fatty acids, and many medications. Because it is produced exclusively in the liver, its level reflects the synthetic capacity of this organ.

Test requirementsNo special requirements
Reference range35–52 g/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Albumin reflects liver function, nutritional status, and kidney function in a single value. In aging research, well-preserved albumin is considered one of the most reliable markers of physical resilience in older age. It is also needed to calculate free testosterone and corrected calcium.

High level

High levels are almost always caused by dehydration and are not a disease in their own right.

Low level

Low levels are found in liver disease, protein loss through the kidneys or intestines, malnutrition, and chronic inflammation.

Frequently asked questions

Why is albumin needed to calculate testosterone?
Some testosterone is loosely bound to albumin and remains biologically available. Albumin and SHBG are therefore needed to calculate free and bioavailable testosterone.

Related markers

Arginine is the precursor to nitric oxide, a messenger that relaxes the smooth muscle in blood vessel walls and thus widens the vessels. This lowers blood pressure and improves blood flow to muscles and organs. Arginine is also part of the urea cycle, through which the body detoxifies ammonia.

Test requirementsFasting, at least 12 hours
Reference range40–120 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Arginine status can provide useful information when assessing vascular health, blood pressure, recovery, and wound healing. The ratio to ADMA can also help assess the function of the inner lining of blood vessels.

High level

High levels are usually caused by supplements.

Low level

Low levels are found when demand is increased after injuries, surgeries, and intense physical exertion.

Frequently asked questions

Does arginine improve athletic performance?
The evidence is mixed. A benefit appears most likely in cases of a confirmed low baseline level or impaired vascular function, not across the board for everyone.

Asparagine was the first amino acid ever isolated – from asparagus juice, which is also where its name comes from. It serves as a nontoxic form for transporting nitrogen in the body and is involved in the formation of glycoproteins, which are important for recognition between cells.

Test requirementsFasting, at least 12 hours
Reference range35–75 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Asparagine is part of the complete amino acid profile and helps assess nitrogen balance overall.

High level

Elevated levels are rare and usually have no clinical significance.

Low level

Low levels occur in cases of severe protein deficiency.

Frequently asked questions

Where does the name asparagine come from?
The amino acid was first extracted from asparagus juice in 1806 – asparagus in Latin – making it the first amino acid ever isolated.

Related markers

Aspartic acid is a nonessential amino acid with two central functions: it channels nitrogen into the urea cycle, through which the body detoxifies ammonia, and it is part of the malate-aspartate shuttle, which transports reducing equivalents into the mitochondria. It is also needed to build genetic material.

Test requirementsFasting, at least 12 hours
Reference rangebelow 25 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

The level supplements the assessment of detoxification capacity and energy metabolism in the amino acid profile.

High level

Elevated levels are found in disorders of the urea cycle.

Low level

Low levels usually have no significance on their own.

Frequently asked questions

Does D-aspartic acid increase testosterone?
Early studies suggested a benefit, but larger, better-controlled studies were unable to confirm the effect in trained men.

Related markers

Bicarbonate is the blood’s main buffer. It neutralizes excess acids and keeps the pH within the very narrow range in which enzymes and cells can function. The lungs and kidneys regulate levels together: the lungs by exhaling carbon dioxide, and the kidneys by reabsorbing bicarbonate.

Test requirementsNo special requirements
Reference range22–29 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

The level shows whether the acid-base balance is in equilibrium. It is measured alongside sodium, potassium, and chloride and helps assess metabolic and kidney disorders.

High level

Elevated levels indicate a shift toward alkalinity, for example after prolonged vomiting or when taking diuretics.

Low level

Low levels indicate acidosis, which can occur with kidney failure, severe diarrhea, or uncontrolled diabetes.

Frequently asked questions

Is bicarbonate the same as “over-acidity” in the alternative medicine sense?
No. The medical term describes a measurable shift in blood pH and is a clearly defined condition. It is not the same as the concept of general tissue acidity.

Related markers

Around 99 percent of calcium is found in bones and teeth, where it provides strength. The remaining one percent in the blood performs essential functions: it controls muscle contraction, nerve signal transmission, and blood clotting. Vitamin D, parathyroid hormone, and calcitonin keep blood levels tightly regulated – even at the expense of the bones.

Test requirementsNo special requirements
Reference range2,15–2,55 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Because the body keeps the blood level constant at all costs, an abnormal calcium level usually points to a problem with the regulatory systems themselves – such as the parathyroid glands, kidneys, or vitamin D balance.

High level

High levels may indicate an overactive parathyroid gland, high-dose vitamin D supplements, or cancer, and should always be investigated.

Low level

Low levels can result from vitamin D deficiency, kidney disease, magnesium deficiency, or an underactive parathyroid gland. Typical symptoms include tingling in the fingers and around the mouth, as well as muscle cramps.

Frequently asked questions

Does the calcium level tell me anything about my bone density?
No. The blood level remains normal for a long time even as bone loss progresses, because the body replenishes calcium from the bones. Bone density requires a DXA scan.

Why is calcium measured together with albumin?
Some calcium is bound to albumin. When albumin is low, total calcium is lower even though there is no actual deficiency – the value is then corrected mathematically.

Chloride is the most abundant negatively charged particle in the blood and accompanies sodium in almost all regulatory processes. It maintains the blood’s electrical neutrality, helps regulate water balance, and provides the basic component for stomach hydrochloric acid.

Test requirementsNo special requirements
Reference range98–107 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Together with sodium and bicarbonate, chloride helps assess acid-base balance. The value helps classify disorders that cannot be explained by the individual values alone.

High level

Elevated levels occur with dehydration, certain kidney disorders, and blood acidification.

Low level

Low levels result from persistent vomiting, diuretic medications, or a shift toward more alkaline blood values.

Frequently asked questions

Is chloride assessed on its own?
No. Chloride must always be considered alongside sodium, potassium, and bicarbonate. Only this combination allows conclusions to be drawn about acid-base balance.

Related markers

Citrulline is part of the urea cycle and is converted to arginine in the kidneys. Unlike arginine, it is not broken down in the intestines and liver, so taking citrulline raises blood arginine levels more reliably – and thus also increases nitric oxide production. It was originally isolated from watermelon.

Test requirementsFasting, at least 12 hours
Reference range20–50 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Citrulline is also an established marker of small intestinal lining function, as it is produced there. Low levels indicate reduced intestinal cell mass.

High level

Elevated levels are found with impaired kidney function and when taking supplements.

Low level

Low levels indicate damage to the small intestinal lining, for example in celiac disease or inflammatory bowel disease.

Frequently asked questions

Why is citrulline more effective than arginine?
Arginine is largely broken down in the intestines and liver. Citrulline passes through both organs and is only converted to arginine in the kidneys, so it raises arginine levels more reliably.

What does citrulline tell us about the gut?
Citrulline is produced in the cells of the small intestinal lining. A low level is considered an indication of reduced functional intestinal cell mass.

Related markers

Cortisol is produced in the adrenal cortex and follows a pronounced daily rhythm: levels are highest shortly after waking and lowest around midnight. It mobilizes energy, maintains blood pressure, and suppresses inflammation. Without cortisol, the body cannot cope with stress.

Test requirementsBlood draw in the morning between 7 and 9 a.m., while rested
Reference range6–23 µg/dl in the morning
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Cortisol helps interpret symptoms such as persistent fatigue, sleep disturbances, muscle loss, and increased abdominal fat. Because levels follow a daily rhythm, the timing of the blood draw is crucial for meaningful results.

High level

Elevated levels are found during acute stress, when taking cortisone medications, during pregnancy, when taking the pill, and in Cushing syndrome.

Low level

Low levels may indicate adrenal insufficiency and should be evaluated by a doctor, as a severe deficiency can be dangerous.

Frequently asked questions

Why does cortisol need to be measured in the morning?
The level fluctuates severalfold over the course of the day. Only a sample taken early in the morning can be meaningfully assessed against the reference ranges.

Does a normal cortisol level mean that I’m not stressed?
No. A single reading is just a snapshot. Trends over the course of the day are more informative when assessing chronic strain.

C-reactive protein is a protein produced in the liver when inflammation occurs in the body. Its level rises measurably within 6 to 12 hours of onset and falls just as quickly once the inflammation subsides. This makes it useful for detecting inflammatory processes and monitoring the progress of treatment.

Test requirementsNo special requirements
Reference rangebelow 5 mg/l (hs-CRP: below 1 mg/l is favorable)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

CRP shows whether inflammation is active in the body – even when no symptoms are noticeable yet. The highly sensitive version is also used to assess long-term cardiovascular risk.

High level

Significantly elevated levels suggest an acute bacterial infection, an injury or an inflammatory disease. Slightly elevated levels can occur with viral infections, excess weight, smoking or intense physical exertion.

Low level

Low levels are normal and are considered unremarkable. However, a low CRP does not rule out inflammation right at the start of an infection.

Frequently asked questions

What does an elevated CRP level mean?
It indicates that inflammation is occurring in the body. The increase is usually much more pronounced with bacterial infections than with viral ones.

What is the difference between CRP and hs-CRP?
The same substance is measured, but with different levels of accuracy. Highly sensitive hs-CRP also detects very low concentrations and is used to assess the risk of cardiovascular disease.

Cystatin C is a small protein produced uniformly by all nucleated cells. It is filtered exclusively by the kidneys and completely broken down there. Unlike creatinine, its level does not depend on muscle mass, making it more reliable for people who are very muscular or very slim.

Test requirementsNo special requirements
Reference range0.53–0.95 mg/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Cystatin C detects declining kidney function earlier than creatinine – often when creatinine still appears completely normal. It is a more informative measure for strength athletes, older adults, and anyone with an unusual body composition.

High level

Elevated levels indicate reduced kidney filtration. An overactive thyroid and high doses of cortisone can also raise the level.

Low level

Low levels are not a concern.

Frequently asked questions

Which is better: creatinine or cystatin C?
Cystatin C is independent of muscle mass and is therefore more reliable for strength athletes, very slim people, and older adults. The most accurate approach is to calculate the filtration rate using both values together.

Does strength training affect the level?
No. That is precisely its advantage over creatinine, which can be elevated in people with a lot of muscle mass even when their kidneys are not impaired.

Related markers

DHEA-S is produced in the adrenal cortex and serves as a precursor that the body uses to produce testosterone and estrogens as needed. It is the most abundant steroid hormone in the blood and, unlike cortisol, shows hardly any daily fluctuations. The level peaks around age 25 and then declines continuously.

Test requirementsNo special requirements
Reference rangeHighly age-dependent, e.g. men aged 30–49: 80–560 µg/dl
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

DHEA-S reflects adrenal cortex function. In women with increased body hair, acne, or menstrual irregularities, the level indicates whether the male hormones originate from the adrenal glands or the ovaries.

High level

Significantly elevated levels indicate increased androgen production by the adrenal glands and should be investigated.

Low level

Low levels are found with adrenal insufficiency, prolonged cortisone therapy, and with age.

Frequently asked questions

Why should DHEA-S be assessed based on age?
The level declines continuously from around age 25. A result can therefore only be meaningfully interpreted in comparison with the appropriate age group.

Serum iron measures the small amount of iron currently circulating in the blood, bound to the transport protein transferrin. The level fluctuates considerably throughout the day and responds immediately to the most recent meal or tablet. That’s why it is not very meaningful on its own and is always assessed alongside ferritin and transferrin.

Test requirementsFasting, in the morning; stop taking iron supplements 24 hours beforehand
Reference rangeWomen: 6.6–26 µmol/l; men: 11–28 µmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Combined with transferrin, this gives the transferrin saturation - the most reliable measure of how well the body is currently supplied with available iron.

High level

Elevated levels occur after taking iron supplements, with liver disease, and in the inherited iron-storage disorder hemochromatosis.

Low level

Low levels suggest iron deficiency, but also occur during acute inflammation, because the body deliberately withholds iron at such times.

Frequently asked questions

Is the iron level alone enough to identify a deficiency?
No. The level fluctuates too much. Ferritin is the most important measure for assessing iron status, supplemented by transferrin and CRP.

Why does iron decrease during a cold?
The body deliberately deprives pathogens of iron by moving it from the blood into storage. A low level during an infection therefore does not automatically mean there is a deficiency.

Related markers

Estradiol is the most potent of the estrogens. In women, it is produced mainly in maturing ovarian follicles and regulates the menstrual cycle, uterine lining, and fertility. It also protects bone density, blood vessels, and brain function. Men also produce estradiol - from testosterone via the enzyme aromatase - and need it for their bones, libido, and fat distribution.

Test requirementsWomen: blood draw on the 3rd to 5th day of the cycle, unless otherwise specified
Reference rangeWomen, depending on cycle phase: 20–400 pg/ml; men: 10–40 pg/ml
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

In women, estradiol helps assess menstrual irregularities, infertility, and menopausal symptoms. In men, an elevated level can explain symptoms such as breast enlargement, fluid retention, and loss of libido - often associated with obesity.

High level

Physiologically elevated in women around mid-cycle. Persistently elevated levels occur with obesity, liver disease, and certain cysts. In men, obesity is the most common cause, since fat tissue converts testosterone into estradiol.

Low level

In women, low levels can indicate menopause, severe underweight, competitive sports, or a pituitary disorder. In men, levels that are too low impair bone density and libido.

Frequently asked questions

When in the cycle should estradiol be measured?
For baseline testing on the third to fifth day of the cycle, together with FSH and LH. Other testing purposes may call for different timing.

Why is estradiol important for men too?
Men need estradiol for bone density, libido, and normal fat metabolism. Both high and low levels cause symptoms.

Related markers

Ferritin is the iron storage protein. It binds iron in the liver, spleen, and bone marrow and releases it when needed. The blood ferritin level gives an approximate indication of how full the iron stores are – and falls long before hemoglobin levels drop.

Test requirementsNo special requirements
Reference rangeWomen 15–150 µg/l, men 30–400 µg/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Ferritin detects iron deficiency at an early stage, before anemia develops. It can often explain typical symptoms such as fatigue, hair loss, difficulty concentrating, or shortness of breath.

High level

High levels result from inflammation, liver disease, heavy alcohol consumption, or iron overload. Because ferritin is also an acute-phase protein, it should always be assessed together with CRP.

Low level

Low levels indicate iron deficiency. Common causes include heavy menstrual bleeding, a diet low in iron, endurance sports, pregnancy, or blood loss in the gastrointestinal tract.

Frequently asked questions

At what ferritin level is it considered iron deficiency?
Levels below 15 µg/l are considered evidence of iron deficiency. Many medical societies consider levels below 30 µg/l to require treatment when typical symptoms are present.

Why is my ferritin normal even though I have symptoms?
When inflammation is present at the same time, ferritin levels rise regardless of iron status and can mask a deficiency. That is why CRP is also measured.

How long does it take to replenish iron stores?
Oral iron therapy usually takes three to six months, although symptoms often improve after just a few weeks.

Related markers

Folate is the natural form of vitamin B9 and is needed for every cell division. The need is especially high where tissue renews quickly: in the bone marrow for blood formation and in early embryonic development. Folate also helps break down homocysteine together with vitamin B12.

Test requirementsFasting recommended
Reference rangeover 4 ng/ml
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Folate deficiency causes anemia with enlarged red blood cells, which can easily be mistaken for B12 deficiency in a blood test. If you are planning to have a child, it is essential to have adequate levels even before conception.

High level

High levels result from supplements and are generally harmless. However, they can mask a simultaneous B12 deficiency in a blood test.

Low level

Causes include a diet low in vegetables, alcohol, chronic bowel disease, pregnancy, and certain medications.

Frequently asked questions

When should you start taking folic acid when trying to conceive?
It is recommended to start at least four weeks before conception, since the neural tube closes in the first weeks of pregnancy—often before the pregnancy is known.

What is the difference between folate and folic acid?
Folate is the natural form found in foods, while folic acid is the synthetic form in supplements. Folic acid is absorbed better, but must first be activated in the body.

Only about one to two percent of testosterone circulates unbound in the blood and can bind directly to cells. This free fraction is not measured directly, but calculated from total testosterone, SHBG, and albumin. The result reflects the actual hormonal effect far better than the total level alone.

Test requirementsBlood draw in the morning between 7 and 11 a.m.
Reference rangeMen 50–210 pg/ml (age- and method-dependent)
Test intervalevery 3 to 6 months
SampleCalculated from blood serum

Why is this level measured?

When SHBG is elevated—for example, in older age, with an overactive thyroid, or while taking estrogen—total testosterone may appear normal while free testosterone is already significantly low. The calculated value identifies precisely these cases.

High level

Elevated levels occur when SHBG is low, for example with obesity, insulin resistance, or polycystic ovary syndrome.

Low level

Low levels despite normal total testosterone indicate elevated SHBG and often explain symptoms that could not be inferred from the total level.

Frequently asked questions

Why is free testosterone calculated instead of measured?
Direct measurement is complex and prone to interference. Calculation from total testosterone, SHBG, and albumin is considered more reliable and is the international standard.

FSH is produced in the pituitary gland and acts directly on the gonads. In women, it stimulates the follicles to grow; in men, it regulates sperm production in the testes. When gonadal function declines, FSH rises—the body is trying to compensate more strongly.

Test requirementsWomen: sample taken on days 3 to 5 of the cycle
Reference rangeWomen, cycle-dependent 3–12 IU/l, men 1.5–12.4 IU/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

FSH is the most important marker for assessing ovarian reserve and detecting menopause. In men, it distinguishes a testicular disorder from a disorder of the higher-level control center.

High level

In women, significantly elevated levels indicate declining ovarian function or menopause. In men, they suggest impaired sperm production.

Low level

Low levels indicate a disorder of the pituitary gland or hypothalamus, for example due to being underweight, intensive athletic training, severe stress, or elevated prolactin.

Frequently asked questions

What does a high FSH level indicate in women?
A clearly elevated FSH level on the third day of the menstrual cycle suggests a reduced ovarian reserve. During menopause, the level rises sharply and remains high.

Related markers

Triiodothyronine is the active form of thyroid hormone. Most of it is not produced in the thyroid itself, but is converted from T4 in the liver, kidneys, and muscles—a process that requires selenium, among other things. T3 regulates basal metabolism, body temperature, and heart rate.

Test requirementsStop taking biotin supplements 2 days beforehand
Reference range2.0–4.4 ng/l (depending on the method)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

fT3 shows whether conversion from the storage form to the active form is actually working. If persistent fatigue occurs despite normal TSH, impaired conversion may be the explanation.

High level

Elevated levels occur with an overactive thyroid and with certain forms of hormone therapy.

Low level

Low levels occur with an underactive thyroid, as well as with serious illness, a severe calorie deficit, or chronic stress—in these cases, the body deliberately slows its energy expenditure.

Frequently asked questions

What does low fT3 with normal TSH mean?
This may indicate reduced conversion of T4 to T3, which can occur with a severe calorie deficit, chronic stress, or serious illness. A doctor should assess the results.

Related markers

Thyroxine is the main hormone secreted by the thyroid. It has only a weak effect of its own and mainly serves as a reserve, which the body uses to produce active T3 when needed. The free fraction, which is not bound to transport proteins, is measured because only this fraction enters the cells.

Test requirementsIf receiving hormone therapy: take the tablet only after the blood draw
Reference range9–19 ng/l (depending on the method)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Together with TSH, fT4 indicates whether a thyroid disorder is mild or severe. It is also used to monitor treatment with thyroid hormones.

High level

Elevated levels suggest an overactive thyroid or hormone therapy at too high a dose. Typical symptoms include a racing heart, nervousness, weight loss, and sweating.

Low level

Low levels combined with high TSH confirm overt hypothyroidism. Low levels combined with low TSH suggest a pituitary disorder.

Frequently asked questions

Why is free T4 measured instead of total T4?
Over 99 percent of T4 is bound to transport proteins and is inactive. Only the free portion enters the cells – which is why it is the meaningful value.

Related markers

Gamma-GT is an enzyme found primarily in the cells of the bile ducts. It is particularly sensitive to alcohol and disruptions in bile flow, making it an important complementary measure alongside other liver values.

Test requirementsNo alcohol in the 3 days before the sample is taken
Reference rangewomen up to 40 U/l, men up to 60 U/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

No other liver value responds so early and so clearly to regular alcohol consumption. Gamma-GT also indicates whether bile flow is impaired.

High level

Typical causes include alcohol, fatty liver, bile duct obstruction, certain medications, and excess weight.

Low level

Low levels are considered harmless.

Frequently asked questions

How long does it take for gamma-GT to drop after giving up alcohol?
The half-life is about two to three weeks. After complete abstinence, the level usually returns to normal within four to eight weeks.

Is elevated gamma-GT always caused by alcohol?
No. Fatty liver, medications, bile duct obstruction, and excess weight are also common causes.

Related markers

Cholesterol is an essential building block of all cell membranes and a precursor to bile acids, vitamin D, and all steroid hormones. The vast majority is produced by the body itself; only a small proportion comes from food. Total cholesterol combines LDL, HDL, and other fractions.

Test requirementsFasting recommended (12 hours)
Reference rangebelow 200 mg/dl
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

This value provides a quick overview of lipid metabolism. However, LDL and HDL levels are crucial for assessing risk – normal total cholesterol can mask an unfavorable ratio.

High level

Causes include genetic predisposition, diet, excess weight, lack of exercise, and an underactive thyroid.

Low level

Very low levels are found in hyperthyroidism, severe liver disease, or malnutrition.

Frequently asked questions

Is low total cholesterol automatically good?
No. What matters is the composition. Low total cholesterol combined with very low HDL is less favorable than a slightly higher value with a good HDL proportion.

Glutamine makes up around 60 percent of the free amino acid pool in muscle and is the most abundant amino acid in the blood. Cells of the intestinal lining and immune system use it as their preferred fuel. During intense exertion, injuries, or infections, consumption rises so sharply that the body’s own production is no longer sufficient - glutamine is then considered conditionally essential.

Test requirementsFasting, at least 12 hours
Reference range420–700 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

For athletes with heavy training loads, recurrent infections, and intestinal complaints, the glutamine level shows whether enough of this key fuel is available.

High level

Elevated levels are usually harmless.

Low level

Low levels are found with overtraining, after surgery, in severe infections, and in chronic intestinal diseases.

Frequently asked questions

Why does glutamine decrease with overtraining?
Intense exertion increases consumption in immune and intestinal cells beyond the rate at which it can be replenished. A low level is therefore considered a possible sign of overload.

Glutamic acid is the most abundant excitatory neurotransmitter in the central nervous system and also a key hub in metabolism: nitrogen groups are transferred between amino acids through it. Glutamine, GABA, and a building block of glutathione are among the substances produced from glutamic acid.

Test requirementsFasting, at least 12 hours
Reference range20–110 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

The value complements the assessment of the amino acid profile and offers clues about the balance between excitatory and inhibitory systems.

High level

Elevated levels are found in liver disease and in cases of impaired ammonia metabolism.

Low level

Low levels are rare and usually have no significance on their own.

Frequently asked questions

Is glutamic acid the same as the flavor enhancer?
The flavor enhancer monosodium glutamate is the sodium salt of glutamic acid. The amino acid itself occurs naturally in almost all protein-rich foods.

Glycine is the simplest amino acid and makes up around one-third of collagen, making it the most abundant building block of skin, tendons, cartilage, and connective tissue. Together with cysteine and glutamate, the body uses it to produce glutathione, its most important antioxidant. In the nervous system, glycine has a calming effect.

Test requirementsFasting, at least 12 hours
Reference range150–400 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Although the body can produce glycine itself, its own production is often insufficient when demand is high. The level can provide useful insights when assessing connective tissue, detoxification capacity, and sleep quality.

High level

Elevated levels are usually harmless.

Low level

Low levels are seen when demand increases due to detoxification processes, collagen formation after injuries, and an unbalanced diet.

Frequently asked questions

Why is glycine considered a longevity amino acid?
Glycine is a precursor to glutathione and is essential for collagen formation. Both systems decline with age, which is why glycine is receiving particular attention in aging research.

Related markers

GPT, known internationally as ALT, is an enzyme found almost exclusively in liver cells. When liver cells are damaged, it enters the bloodstream. Because GPT is so concentrated in the liver, it is considered the most specific of the traditional liver values.

Test requirementsNo intensive training for 2–3 days beforehand
Reference rangeWomen up to 35 U/L, men up to 50 U/L
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

GPT is the most sensitive early indicator of liver stress. It often rises before symptoms appear - for example, with fatty liver, regular alcohol consumption, or viral hepatitis.

High level

The most common cause of mildly elevated levels today is non-alcoholic fatty liver disease. Other causes include alcohol, certain medications, viral hepatitis, and very intensive strength training.

Low level

Low levels generally have no clinical significance.

Frequently asked questions

What does an elevated GPT level mean?
It indicates damage to or stress on liver cells. The most common cause in Germany is fatty liver, followed by alcohol and medications.

How can liver values be lowered?
Effective measures include avoiding alcohol, losing weight if overweight, getting more exercise, and reviewing medications and supplements.

Related markers

When sugar is present in the blood, it binds to the red blood pigment hemoglobin. Because red blood cells live for about 120 days, the proportion of this glycated hemoglobin shows what the average blood sugar level has been over the past two to three months.

Test requirementsNo special requirements
Reference rangebelow 5.7% (prediabetes 5.7–6.4%, diabetes 6.5% or higher)
Test intervalevery 3 to 6 months
MaterialEDTA whole blood

Why is this level measured?

Unlike fasting blood glucose, HbA1c is unaffected by a single meal or the time of day. It is therefore the key measure for detecting prediabetes and monitoring diabetes over time.

High level

Levels of 5.7 percent or higher are considered prediabetes, and levels of 6.5 percent or higher meet the criterion for diabetes mellitus. Iron deficiency anemia can also slightly raise the value.

Low level

Low levels are usually not a concern. If red blood cells have a shortened lifespan, the value may be falsely low.

Frequently asked questions

Do you need to fast for an HbA1c test?
No. HbA1c can be measured at any time of day and regardless of meals – this is one of its major advantages over fasting blood sugar.

How quickly does HbA1c change?
Because it reflects an average over several weeks, a lifestyle change only shows a clear effect on the value after about eight to twelve weeks.

HDL takes up cholesterol from tissues and blood vessel walls and carries it back to the liver, where it is broken down. This return transport is why it is called good cholesterol.

Test requirementsFasting recommended (12 hours)
Reference rangeWomen over 45 mg/dl, men over 40 mg/dl
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

HDL is measured together with LDL and triglycerides as part of a lipid profile and is included in common cardiovascular risk calculators.

High level

Higher levels were long considered beneficial across the board. However, current knowledge indicates that very high levels above 90 mg/dl provide no additional protection.

Low level

Low levels are considered an independent risk factor. They often occur alongside excess weight, lack of exercise, smoking, and elevated triglycerides.

Frequently asked questions

How can HDL be increased?
Regular aerobic exercise, not smoking, and weight loss are most effective. Studies have shown no benefit from medications that specifically raise HDL.

Which is more important, HDL or LDL?
LDL is the decisive and treatable value for assessing risk. HDL is also considered, but is not an independent treatment target.

Histidine is essential for children and can only be produced in limited amounts by adults. It is used to make histamine, the key messenger in allergic reactions, stomach acid production, and nerve signaling. Histidine is also part of hemoglobin and buffers acids in the muscles.

Test requirementsFasting, at least 12 hours
Reference range60–120 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Low levels are associated with anemia and chronic inflammatory diseases. The value complements the assessment of iron status and inflammatory markers.

High level

Elevated levels are rare and usually diet-related.

Low level

Low levels are seen in chronic inflammation, rheumatic diseases, and iron deficiency anemia.

Frequently asked questions

Is histidine related to histamine intolerance?
Histidine is a precursor of histamine. However, with histamine intolerance, the problem lies in the breakdown of histamine, not in the intake of histidine.

Related markers

Only about 20 percent of the vitamin B12 in the blood is bound to transcobalamin and can actually be taken up by cells. Holo-transcobalamin measures precisely this usable portion. The rest circulates bound to another protein and is not available to the metabolism.

Test requirementsStop taking B12 supplements several days beforehand
Reference rangeabove 50 pmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Holo-TC is the earliest marker of B12 deficiency and decreases even when total B12 is still within the normal range. This allows you to take action before nerve damage occurs.

High level

High levels are harmless and usually result from supplementation.

Low level

Levels below 35 pmol/l indicate a deficiency. Levels between 35 and 50 pmol/l are considered a gray area and are usually supplemented with methylmalonic acid or homocysteine testing.

Frequently asked questions

Which is better: total B12 or Holo-TC?
Holo-TC measures the biologically active portion and detects a deficiency much earlier. Total B12 levels can still be normal even when a deficiency is beginning.

Homocysteine is formed as an intermediate product when the amino acid methionine is broken down. It is normally processed quickly – the body needs folic acid, vitamin B12, and vitamin B6 for this. If any of these vitamins are lacking, homocysteine builds up and damages the inner walls of blood vessels.

Test requirementsFasting
Reference rangebelow 10 µmol/l
Test intervalevery 3 to 6 months
SampleEDTA plasma, refrigerated immediately

Why is this level measured?

Elevated homocysteine is considered an independent risk factor for vascular disease and is also associated with cognitive decline. The big advantage: elevated levels can usually be lowered effectively with B vitamins.

High level

Causes include a deficiency in folic acid, B12, or B6, impaired kidney function, smoking, high coffee consumption, and a genetic variant affecting folate metabolism.

Low level

Low levels are beneficial and are not clinically significant.

Frequently asked questions

How can elevated homocysteine levels be lowered?
In most cases, targeted supplementation with folic acid, vitamin B12, and vitamin B6 is effective after measuring the levels of each vitamin.

Why does the sample need to be processed quickly?
After the blood draw, red blood cells continue to release homocysteine. If the sample is not cooled and centrifuged promptly, the result will be falsely high.

Like leucine and valine, isoleucine is a branched-chain amino acid. It is metabolized directly in the muscles rather than in the liver, where it serves as a readily available energy source. It also promotes glucose uptake into muscle cells.

Test requirementsFasting, at least 12 hours
Reference range40–110 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Isoleucine is assessed together with leucine and valine. The pattern of the three values provides clues about protein intake, recovery capacity, and physical strain.

High level

High levels result from high protein intake or supplements.

Low level

Low levels indicate insufficient protein intake or increased demands from training.

Frequently asked questions

Why are BCAAs always considered together?
Leucine, isoleucine, and valine share the same transport and breakdown pathways. Only the ratio between the three values allows for a meaningful assessment.

Related markers

Around 98 percent of the body's potassium is inside cells. The concentration gradient outward creates the electrical voltage that nerve and muscle cells need to function, including heart muscle cells. Even small deviations in the blood can therefore have noticeable effects. Regulation is mainly handled by the kidneys and the hormone aldosterone.

Test requirementsBlood draw without prolonged tourniquet use
Reference range3,5–5,1 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Potassium is one of the few lab values where both high and low levels can become immediately dangerous because they can trigger heart rhythm disorders. Typical symptoms include muscle weakness, cramps, constipation, and palpitations.

High level

Causes include impaired kidney function, potassium-sparing diuretics, certain blood pressure medications, and severe cell breakdown. Blood tests taken after prolonged tourniquet use can also produce falsely high results.

Low level

Causes include diuretics, persistent vomiting or diarrhea, laxative abuse, heavy sweating, and magnesium deficiency, which often sustains potassium deficiency.

Frequently asked questions

Which foods are high in potassium?
Foods rich in potassium include bananas, apricots, potatoes, legumes, nuts, spinach, and tomato paste. People with impaired kidney function should coordinate their intake with a doctor.

Why are potassium and magnesium connected?
Magnesium deficiency causes the kidneys to excrete more potassium. Potassium deficiency can therefore often only be corrected in the long term if magnesium levels are also brought back into balance.

Related markers

Copper is needed for the absorption and incorporation of iron into red blood pigment. It is also part of enzymes that stabilize connective tissue and vessel walls, produce pigments, and protect nerve cells. In the blood, it is transported mainly bound to the protein ceruloplasmin.

Test requirementsNo special requirements
Reference range11–22 µmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Copper deficiency can cause anemia that cannot be corrected with iron alone. It occurs mainly with consistently high zinc intake and after gastrointestinal surgery.

High level

Elevated levels are found with inflammation, during pregnancy, when taking estrogen-containing preparations, and in liver disease.

Low level

Low levels can result from high-dose zinc supplements, chronic intestinal diseases, or bariatric surgery.

Frequently asked questions

Why are copper and zinc considered together?
Both trace elements compete for the same transport pathways in the intestine. A consistently high zinc intake can therefore cause copper deficiency - the ratio between the two levels is more informative than either level alone.

Related markers

LDL transports cholesterol from the liver to the tissues. When there is too much of it in the blood, it builds up in the vessel walls and forms plaques - the beginning of atherosclerosis. That's why LDL is commonly called bad cholesterol.

Test requirementsFasting recommended (12 hours)
Reference rangedepends on risk: below 116 mg/dl for low risk, below 70 mg/dl for high risk
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

The link between LDL levels and cardiovascular risk is one of the best-established in medicine. The target level is not the same for everyone; it depends on a person's overall risk.

High level

Elevated levels can result from genetic predisposition, diet, being overweight, lack of exercise, and an underactive thyroid. Very high levels may indicate familial hypercholesterolemia.

Low level

Low levels are considered beneficial for the heart and blood vessels and are generally harmless.

Frequently asked questions

Is there a general normal LDL level?
No. The appropriate target level depends on overall cardiovascular risk. Someone who has already had a heart attack needs a significantly lower level than a healthy young person.

How can LDL be lowered?
Effective measures include replacing saturated fats with unsaturated fats, increasing fiber intake, losing weight, and exercising. If these measures are not enough, medication may be considered.

Leucine is an essential, branched-chain amino acid that the body cannot produce on its own. It is not only a building block of muscle protein but also a signaling molecule: leucine activates the mTOR signaling pathway, which initiates muscle protein synthesis. This makes it the key amino acid for anabolism.

Test requirementsFasting for at least 12 hours; avoid protein shakes for 24 hours beforehand
Reference range75–200 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Leucine status shows whether protein intake is sufficient for muscle building and recovery. This is especially relevant during intensive training, in older age, and with a plant-focused diet.

High level

Elevated levels result from high protein intake or supplements. Persistently elevated branched-chain amino acids are associated with insulin resistance.

Low level

Low levels occur with insufficient protein intake, during periods of heavy exertion, and with intestinal absorption disorders.

Frequently asked questions

How much leucine do you need to build muscle?
A threshold of about 2.5 to 3 grams of leucine per meal is considered necessary to stimulate muscle protein synthesis. This amount is found in around 25 to 30 grams of high-quality protein.

Related markers

Like FSH, LH comes from the pituitary gland. In women, a sharp rise in LH around mid-cycle triggers ovulation – this is exactly the rise measured by ovulation tests from the pharmacy. In men, LH stimulates the Leydig cells in the testes to produce testosterone.

Test requirementsWomen: sample taken on days 3 to 5 of the cycle
Reference rangeWomen: cycle-dependent, 2–12 IU/l; men: 1.7–8.6 IU/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

In men, LH together with testosterone helps determine the cause of a deficiency: high LH means the problem lies in the testes. Low LH means the problem is in the higher-level regulatory system. In women, the LH-to-FSH ratio helps assess PCOS.

High level

Physiologically elevated in women around mid-cycle and persistently elevated during menopause; also common in PCOS. In men, high LH with low testosterone points to a testicular disorder.

Low level

Low levels point to a pituitary gland disorder – for example, due to elevated prolactin, severe underweight, or the use of testosterone preparations.

Frequently asked questions

What does a high LH-FSH ratio mean?
An LH level significantly higher than FSH may indicate PCOS. Ultrasound and additional hormone levels are also needed for diagnosis.

Related markers

Lipoprotein (a) is an LDL-like particle with an additional protein attachment. Its concentration is more than 90 percent genetically determined and remains largely constant throughout life. It promotes both the calcification of blood vessels and the formation of blood clots.

Test requirementsNo special requirements
Reference rangeunder 30 mg/dl
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Lp(a) explains some heart attacks in people whose other levels are unremarkable. Because the level remains constant, usually just one test in a lifetime is enough – but it has far-reaching implications for prevention.

High level

About one in five people has elevated levels. Since lifestyle has little effect on them, treatment focuses on lowering all other risk factors – especially LDL – more consistently.

Low level

Low levels are considered favorable and require no action.

Frequently asked questions

Why is Lp(a) measured only once?
The level is genetically determined and changes very little over a lifetime. A single test is therefore enough to assess lifetime risk.

Can Lp(a) be lowered?
Practically not through diet or exercise. The focus is therefore on factors that can be changed. Medications specifically designed to lower Lp(a) are in development.

Lysine is an essential amino acid and a key building block of collagen – the structural protein in skin, tendons, ligaments, and bones. Together with methionine, the body uses it to make carnitine, which transports fatty acids into the mitochondria to produce energy. Lysine also promotes calcium absorption from the intestine.

Test requirementsFasting, at least 12 hours
Reference range120–280 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Grains contain little lysine, which is why it can be the limiting amino acid in grain-heavy or vegan diets. The level indicates whether there are enough building blocks for connective tissue and bones.

High level

Elevated levels are usually due to diet or supplements.

Low level

Low levels are found with grain-heavy diets, vegan diets without legumes, and increased needs during periods of growth or recovery.

Frequently asked questions

Which foods are high in lysine?
Meat, fish, eggs, dairy products, and legumes are rich in lysine. Grains are comparatively low in it.

Magnesium is involved in many metabolic processes, including energy production, muscle relaxation, and nerve signal transmission. Most of it is found in bones and cells, with only about one percent of the total circulating in the blood.

Test requirementsNo special requirements
Reference range0.75–1.05 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Typical symptoms of deficiency include muscle cramps, tension, eyelid twitching, restlessness, and palpitations. Athletes also lose measurable amounts through sweat.

High level

Elevated levels are rare and are usually caused by impaired kidney function or high-dose supplements.

Low level

Causes include an unbalanced diet, alcohol, chronic diarrhea, diuretics, acid blockers, and high losses through sweat.

Frequently asked questions

Why is my magnesium level normal even though I have symptoms?
Only around one percent of the body's total magnesium circulates in the blood. The body keeps this level constant by releasing magnesium from the bones - so a tissue deficiency can exist despite a normal serum level.

When is the best time to take magnesium?
Taking it in the evening is often recommended because magnesium relaxes muscles. Consistency is what matters most.

Related markers

Methionine is an essential, sulfur-containing amino acid and is the starting point for all protein synthesis. It is used to produce SAM, the body's most important methyl-group donor, which is involved in regulating genes, producing neurotransmitters, and detoxification processes. Homocysteine is produced when it is broken down.

Test requirementsFasting, at least 12 hours
Reference range15–45 µmol/l (depends on method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Methionine is directly related to homocysteine levels and the need for folic acid, B12, and B6. This value helps assess disorders of methylation metabolism.

High level

Elevated levels occur with very high-protein diets and certain liver diseases.

Low level

Low levels indicate an inadequate protein intake.

Frequently asked questions

Are methionine and homocysteine related?
Yes, directly. Homocysteine is produced when methionine is broken down. If folic acid, B12, or B6 is lacking, homocysteine builds up.

Sodium is the most abundant positively charged particle in the space between cells. It determines how much water the body retains in circulation, so it is directly involved in regulating blood volume and blood pressure. Together with potassium, sodium also generates the electrical potential across cell membranes, which nerves and muscles need to function. Its level is very tightly regulated by the kidneys and the hormone ADH.

Test requirementsNo special requirements
Reference range135–145 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

The sodium level shows whether the balance of water and salt is in equilibrium. Deviations often develop gradually and cause nonspecific symptoms such as confusion, headaches, nausea, or muscle weakness.

High level

Elevated levels are almost always caused by a lack of fluids – for example, drinking too little, heavy sweating, fever, or diarrhea. Hormonal causes are less common.

Low level

Low levels are the most common electrolyte disorder. Causes include diuretic medications, heart, liver, or kidney disease, very high fluid intake during endurance sports, and certain antidepressants.

Frequently asked questions

What does a low sodium level mean?
Usually, this is not a salt deficiency but an excess of water – the sodium is diluted. Common causes include diuretic medications or drinking very large amounts during prolonged endurance exercise.

Can I control my sodium level through diet?
Only to a limited extent. Healthy kidneys compensate very reliably for fluctuations in salt intake. The blood level therefore says little about salt consumption.

Related markers

Ornithine is not incorporated into proteins, but acts as the hub of the urea cycle: it takes up ammonia produced during protein breakdown and enables its conversion into harmless urea. Ammonia is particularly harmful to the brain, which is why this cycle is vital.

Test requirementsFasting, at least 12 hours
Reference range30–110 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

With a very high-protein diet, liver disease, or fatigue caused by exertion, ornithine shows whether ammonia detoxification is keeping up with the load.

High level

Elevated levels are found in disorders of the urea cycle.

Low level

Low levels suggest increased consumption under a high protein load.

Frequently asked questions

How are ornithine, citrulline, and arginine related?
All three are stages in the same urea cycle. They convert into one another and are therefore assessed together.

Related markers

Phenylalanine is an essential amino acid that the body converts into tyrosine. Tyrosine is then used to produce the neurotransmitters dopamine, noradrenaline, and adrenaline, as well as thyroid hormones. Phenylalanine is therefore the starting point of a chain that regulates motivation, alertness, and the stress response.

Test requirementsFasting, at least 12 hours
Reference range35–85 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

The phenylalanine-to-tyrosine ratio shows whether the conversion is working. A disruption can affect motivation and concentration.

High level

Markedly elevated levels are found in the inherited metabolic disorder phenylketonuria, which is detected through newborn screening.

Low level

Low levels suggest inadequate protein intake.

Frequently asked questions

What is phenylketonuria?
An inherited metabolic disorder in which phenylalanine cannot be converted into tyrosine. It is detected through newborn screening in Germany and requires a lifelong diet.

Related markers

Together with calcium, phosphate forms the hard substance of bones and teeth. It is also found in every ATP molecule, the cell’s universal energy currency, as well as in genetic material and all cell membranes. Its level is closely coordinated with calcium balance.

Test requirementsFasting recommended
Reference range0.84–1.45 mmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Phosphate helps assess calcium, vitamin D, and kidney function. Abnormal levels are an early indication of problems with bone and mineral metabolism.

High level

Elevated levels are found mainly with impaired kidney function, as phosphate can no longer be excreted adequately.

Low level

Low levels occur with vitamin D deficiency, alcohol dependence, severe malnutrition, or as a result of phosphate-binding medications.

Frequently asked questions

Am I getting too much phosphate from processed foods?
Phosphate additives in processed foods and cola drinks are absorbed much more readily than naturally occurring phosphate. This is usually not a problem for people with healthy kidneys, but it is relevant in kidney disease.

Related markers

After ovulation, progesterone is produced by the corpus luteum, which develops from the emptied ovarian follicle. It prepares the uterine lining for implantation, maintains an existing pregnancy, and has a calming effect on the nervous system. If ovulation does not occur, progesterone levels do not rise either.

Test requirementsSample taken about 7 days after ovulation (around day 21 of a 28-day cycle)
Reference rangemid-luteal phase: above 3 ng/ml confirms ovulation; above 10 ng/ml suggests adequate corpus luteum function
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

A progesterone level measured about seven days after ovulation is the simplest evidence that ovulation actually occurred. This is the key information when trying to conceive, with menstrual cycle disorders, and with premenstrual symptoms.

High level

Elevated levels are normal in the second half of the cycle and during pregnancy.

Low level

Low levels in the second half of the cycle suggest that ovulation has not occurred or that the corpus luteum is underfunctioning. Common triggers include stress, being underweight, competitive sports, thyroid disorders, and PCOS.

Frequently asked questions

When is progesterone measured?
About seven days after ovulation, which is around day 21 in a 28-day cycle. With longer or irregular cycles, the timing shifts accordingly.

What does low progesterone mean?
Usually, ovulation has not occurred or the corpus luteum is not functioning adequately. Both are common and readily investigated causes of difficulty conceiving.

Related markers

Prolactin is produced in the pituitary gland and stimulates milk production after childbirth. Outside pregnancy and breastfeeding, elevated levels inhibit the release of FSH and LH—and thus the entire sex hormone axis. Prolactin levels are sensitive to stress, sleep, and physical exertion.

Test requirementsIn the morning, well-rested, seated for at least 20 minutes before the blood draw; no exercise or sexual intercourse the day before
Reference rangeWomen under 25 ng/ml, men under 18 ng/ml
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Elevated prolactin is a common and easily treatable cause of missed periods, difficulty conceiving, and loss of libido—in both women and men.

High level

Causes include stress, certain medications such as antipsychotics and stomach medicines, an underactive thyroid, and benign tumors of the pituitary gland.

Low level

Low levels generally have no clinical significance.

Frequently asked questions

Why should you rest before a prolactin test?
Prolactin rises with stress, physical exertion, and even the blood draw itself. Resting for at least 20 minutes prevents falsely high results.

What should you do if prolactin is elevated?
First, the test is repeated under optimal conditions and the thyroid is checked. If the result is confirmed, the pituitary gland is then investigated by a doctor.

Related markers

Proline is a non-essential amino acid with a unique ring structure that gives collagen its characteristic stability. To be incorporated, proline is converted into hydroxyproline—a step that requires vitamin C. Without enough vitamin C, collagen remains unstable.

Test requirementsFasting, at least 12 hours
Reference range120–400 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

For questions about skin aging, joint problems, wound healing, and vascular elasticity, proline shows whether the building blocks for collagen formation are available.

High level

Elevated levels are usually harmless.

Low level

Low levels occur when requirements are increased during healing and with a low-protein diet.

Frequently asked questions

Why does collagen formation need vitamin C?
Vitamin C is needed to convert proline into hydroxyproline. Only this form gives collagen its tensile strength—which is why vitamin C deficiency used to cause scurvy.

Prostate-specific antigen is a protein produced exclusively in the prostate that normally liquefies semen. A small amount enters the bloodstream. If the prostate grows or becomes inflamed, or a tumor develops there, the measurable amount in the blood increases.

Test requirementsNo cycling, sexual intercourse, or rectal examination for 48 hours beforehand
Reference rangeunder 4 ng/ml (age-dependent)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

PSA is the only widely available test for early detection of prostate cancer. It is organ-specific but not cancer-specific—elevated levels often have harmless causes. Changes over time are more informative than a single result.

High level

In addition to a tumor, possible causes include benign enlargement, inflammation of the prostate, cycling, sexual intercourse, or a rectal examination shortly before the blood sample is taken.

Low level

Low levels are considered normal. Certain medications for benign prostate enlargement halve PSA levels, which must be taken into account when interpreting the results.

Frequently asked questions

Does an elevated PSA level mean cancer?
No. Most elevated values have harmless causes, such as benign enlargement or inflammation. An abnormal result should be checked and evaluated by a urologist.

When should PSA be measured?
Medical societies recommend screening from age 45, or from age 40 if there is a family history. The decision should be made after consulting a doctor.

Selenium is part of enzymes that protect cells from oxidative stress. It is especially important for the thyroid: converting the storage hormone T4 into the active T3 depends on selenium, and the organ contains the highest concentration of selenium in the entire body. The soils in Central Europe are low in selenium, which means intake from plant-based foods is lower here than in other regions.

Test requirementsNo special requirements
Reference range70–130 µg/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Selenium deficiency can impair thyroid function and contribute to autoimmune processes. The immune system and fertility also depend on an adequate supply.

High level

Very high levels result from taking excessive supplements and can lead to hair loss, brittle nails, and garlic-like breath. The gap between the required amount and too much is relatively small for selenium.

Low level

Low levels are found in people following a purely plant-based diet, people with chronic intestinal diseases, and people with thyroid disorders.

Frequently asked questions

Which foods are high in selenium?
Brazil nuts contain by far the most, followed by fish, eggs, meat, and organ meats. Just a few Brazil nuts per week are enough – more can already put you in the overdose range.

Does selenium help with Hashimoto’s?
Studies show that selenium supplementation can lower antibody levels when a deficiency has been confirmed. Taking it without testing first is not advisable because the therapeutic window is narrow.

Related markers

The body can produce serine itself. It is a precursor to phospholipids, which are components of every cell membrane and especially the sheaths of nerve cells. In folate metabolism, serine provides the methyl groups needed to break down homocysteine and regulate genes. Glycine is also produced from it.

Test requirementsFasting, at least 12 hours
Reference range70–180 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Serine connects nerve metabolism and methylation. Abnormal levels help identify issues in these closely linked systems.

High level

Elevated levels are rare and usually have no independent significance.

Low level

Low levels may indicate increased use in methylation metabolism.

Frequently asked questions

How are serine and glycine related?
The body can convert serine into glycine and vice versa. The two levels are therefore considered together.

Related markers

SHBG is produced in the liver and binds testosterone and estradiol in the blood. Bound hormones are not available to cells. This means SHBG plays a major role in determining how strongly hormones actually affect the body – two people with identical testosterone levels can feel completely different if their SHBG levels differ.

Test requirementsBlood sample taken in the morning
Reference rangeMen 18–54 nmol/l, women 32–128 nmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Free testosterone cannot be calculated without SHBG. In addition, the level is a sensitive indicator of insulin resistance: Low SHBG often precedes type 2 diabetes by years.

High level

Elevated levels are found with hyperthyroidism, liver disease, older age, estrogen use and pregnancy.

Low level

Low levels occur with excess weight, insulin resistance, hypothyroidism and PCOS.

Frequently asked questions

What does low SHBG mean?
It is often an early indication of insulin resistance and typically occurs together with excess weight and elevated triglycerides.

Why do I need SHBG if testosterone has already been measured?
Because SHBG shows which proportion of testosterone can actually have an effect. Without this value, total testosterone is often misleading.

Strictly speaking, taurine is not a classic amino acid because it is not incorporated into proteins. It occurs freely in cells, particularly in the heart, muscles, retina and nervous system. There, it stabilizes cell membranes, regulates calcium balance and protects against oxidative stress. It is also needed for the production of bile acids.

Test requirementsFasting for at least 12 hours; no energy drinks the day before
Reference range40–120 µmol/l (depending on the method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Taurine levels decline significantly with age, which is why they receive particular attention in aging research. They also provide useful insights into heart health and recovery after exertion.

High level

Elevated levels result from supplements or taurine-containing drinks and are considered harmless.

Low level

Low levels are found in people on a purely plant-based diet, since taurine occurs almost exclusively in animal-based foods, as well as when demand increases under physical strain.

Frequently asked questions

Why is taurine considered a longevity marker?
Levels decline considerably over the course of life. Animal studies have shown that taurine supplementation extends lifespan, but robust data in humans are still lacking.

Do vegans need taurine?
Taurine is found almost exclusively in animal-based foods. Although the body can produce it itself, levels are measurably lower on a purely plant-based diet.

Related markers

In men, testosterone is produced mainly in the testes; in women, smaller amounts are produced in the ovaries and adrenal cortex. It affects muscle mass, bone density, fat distribution, mood, motivation and libido. Most of it in the blood is bound to SHBG and albumin; only a small proportion is available in free form.

Test requirementsBlood draw in the morning between 7 and 11 a.m.
Reference rangeMen 3.0–10.0 ng/ml, women 0.1–0.8 ng/ml
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Falling levels cause nonspecific symptoms, such as lack of motivation, muscle loss, increased abdominal fat, sleep problems or reduced libido. The lab result helps put these symptoms into context.

High level

In women, elevated levels may indicate polycystic ovary syndrome (PCOS), often accompanied by menstrual irregularities, acne and increased body hair. In men, very high levels are almost always due to external supplementation.

Low level

Causes include age, excess weight, chronic stress, lack of sleep, diseases of the testes or pituitary gland, and certain medications.

Frequently asked questions

When should testosterone be measured?
In the morning between 7 and 11 a.m., because levels follow a daily rhythm and are highest in the morning. For a reliable result, two measurements on different days are recommended.

Why isn't total testosterone always enough?
When SHBG levels are altered, total testosterone can be normal even though too little free hormone is available. In that case, free testosterone needs to be calculated.

Thyroglobulin is the storage protein in which the thyroid stores its hormones. When the immune system targets it, thyroglobulin antibodies are produced. They usually occur alongside TPO antibodies, but sometimes appear on their own.

Test requirementsNo special requirements
Reference rangebelow 115 IU/ml (method-dependent)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Tg antibodies fill the gap when an autoimmune process is suspected but TPO antibodies are negative. They are also important in thyroid cancer follow-up because they can interfere with measurement of the tumor marker thyroglobulin.

High level

Elevated values indicate an autoimmune thyroid disease, most commonly Hashimoto's thyroiditis.

Low level

Negative values are normal.

Frequently asked questions

When are Tg antibodies measured?
Especially when an autoimmune thyroid disease is suspected but TPO antibodies are normal.

Related markers

Threonine is an essential amino acid and an important component of collagen and elastin. The need is particularly high in the intestinal mucosa: threonine is the main building block of mucin, the protective layer that lines the intestinal wall. It is also needed to produce antibodies.

Test requirementsFasting, at least 12 hours
Reference range90–250 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

A threonine deficiency can impair the gut barrier function and immune defenses. This makes the level informative when investigating digestive symptoms and recurrent infections.

High level

Elevated levels are rare and usually diet-related.

Low level

Low levels are found with a low-protein diet and in chronic intestinal diseases with increased consumption.

Frequently asked questions

What role does threonine play in the gut?
It is the main building block of the mucus layer that protects the intestinal wall. In chronic intestinal inflammation, consumption increases significantly.

Thyroid peroxidase is an enzyme the thyroid needs to produce hormones. In an autoimmune disease, the immune system attacks this enzyme and produces antibodies against it. These can be detected in the blood, often years before thyroid function measurably declines.

Test requirementsNo special requirements
Reference rangebelow 34 IU/ml (depending on method)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

TPO antibodies are the key measure for distinguishing Hashimoto's thyroiditis from other causes of an underactive thyroid. They also have added significance when trying to conceive and during pregnancy, as they increase the risk of complications.

High level

Elevated levels are found in over 90 percent of people with Hashimoto's thyroiditis, and less frequently in people with Graves' disease. The level does not indicate the severity of the disease.

Low level

Negative results make autoimmune thyroid disease unlikely, but do not rule it out completely.

Frequently asked questions

Do I need to have my TPO antibodies checked regularly?
No. Once the diagnosis has been made, changes in antibody levels do not affect treatment. TSH and thyroid hormones are monitored instead.

Do I have Hashimoto's if my antibody levels are elevated?
Elevated antibodies confirm an autoimmune process. Whether and when this leads to an underactive thyroid requiring treatment can only be determined by tracking TSH and fT4 over time.

Related markers

Transferrin binds iron in the blood and carries it where it is needed - especially to the bone marrow for blood formation. The liver adjusts production to meet demand: transferrin increases when iron is deficient and decreases when there is an iron surplus. Transferrin saturation can be calculated from iron and transferrin.

Test requirementsFasting, in the morning
Reference range2.0–3.6 g/l (saturation 16–45 %)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Transferrin saturation is the most reliable measure for distinguishing a true iron deficiency from inflammation-related iron sequestration - precisely where ferritin alone reaches its limits.

High level

High levels indicate iron deficiency: the body produces more transport protein to make better use of scarce iron. Estrogen supplements and pregnancy also raise the level.

Low level

Low levels occur with chronic inflammation, liver disease, malnutrition, and iron overload.

Frequently asked questions

What is transferrin saturation?
It indicates what proportion of the transport capacity is actually occupied by iron. Values below 16 percent suggest iron deficiency, while values above 45 percent suggest iron overload.

Related markers

Triglycerides are the most common form of fat in the body. They come from food and are also produced in the liver from excess carbohydrates. In the blood, they serve as an energy source and are stored in fat cells.

Test requirementsFasting for 12 hours, no alcohol the day before
Reference rangeunder 150 mg/dl (fasting)
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

Elevated triglycerides are a component of metabolic syndrome and an indication of insulin resistance. Very high levels can also trigger pancreatitis.

High level

Causes include alcohol, a diet high in sugar, excess weight, insulin resistance, and genetic predisposition. A blood test taken without fasting also significantly raises the level.

Low level

Low levels are generally harmless.

Frequently asked questions

Why do you have to fast for a triglyceride test?
Triglyceride levels rise sharply after a meal. To get a comparable result, you should fast for about twelve hours and avoid alcohol during this time as well.

How do you lower elevated triglycerides?
Avoiding alcohol and reducing sugar and refined carbohydrates have the fastest effects. Weight loss, exercise, and omega-3 fatty acids can also help.

Tryptophan is the rarest of the essential amino acids. Some of it is converted into serotonin, the neurotransmitter that influences mood, appetite, and sleep, and then further into melatonin. Another portion is broken down via the kynurenine pathway, which becomes more active during inflammation, leaving less tryptophan available for serotonin production.

Test requirementsFasting, at least 12 hours
Reference range40–80 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Low tryptophan levels are associated with low mood, sleep problems, and cravings. In chronic inflammation, the level explains why these symptoms often occur together.

High level

Elevated levels are rare and usually caused by supplements.

Low level

Low levels are found with low-protein diets, chronic inflammation, and severe stress.

Frequently asked questions

Does tryptophan make you sleepy?
Tryptophan is a precursor to serotonin and melatonin. Whether taking it actually improves sleep depends greatly on its uptake into the brain, where it competes with other amino acids.

Related markers

TSH is produced in the pituitary gland and regulates the thyroid. If the thyroid produces too few hormones, the body releases more TSH to stimulate it. If it produces too much, TSH levels fall. The value therefore moves in the opposite direction to thyroid function - a high TSH means an underactive thyroid.

Test requirementsDiscontinue biotin supplements 2 days beforehand; have the sample taken at approximately the same time of day
Reference range0.4–4.0 mU/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

TSH is the most sensitive single measure of thyroid function and responds earlier than the thyroid hormones themselves. It is therefore the standard screening test for fatigue, weight changes, hair loss, feeling cold, or a racing heart.

High level

Elevated TSH suggests an underactive thyroid. The most common cause is the autoimmune disease Hashimoto's thyroiditis.

Low level

Low TSH indicates an overactive thyroid, for example in Graves' disease, with autonomous nodules, or when thyroid medication is dosed too high.

Frequently asked questions

What does an elevated TSH level mean?
Elevated TSH means the body has to stimulate the thyroid more strongly - a sign of an underactive thyroid. fT3, fT4, and antibodies are usually tested to investigate further.

Does TSH fluctuate throughout the day?
Yes, TSH follows a daily rhythm, with the highest levels at night and in the early morning. For good comparability, the sample should always be taken at a similar time of day.

Does biotin affect the test?
Yes. High-dose biotin from dietary supplements can significantly distort thyroid test results and should be discontinued about two days beforehand.

Related markers

Tyrosine is produced from phenylalanine and is a precursor to several key substances: the thyroid hormones T3 and T4, the neurotransmitters dopamine, norepinephrine, and epinephrine, and melanin, the pigment in skin and hair.

Test requirementsFasting, at least 12 hours
Reference range40–90 µmol/l (method-dependent)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

In cases of low energy, concentration problems, and thyroid disorders, tyrosine shows whether the basic building block for these systems is even available.

High level

Elevated levels are found in liver disease and rare inherited metabolic disorders.

Low level

Low levels occur with a low-protein diet and impaired conversion from phenylalanine.

Frequently asked questions

Does tyrosine help with hypothyroidism?
Tyrosine is a necessary building block of thyroid hormones, but it is rarely the limiting factor. It cannot be used to treat hypothyroidism.

Valine is an essential amino acid that the body cannot produce. Together with leucine and isoleucine, it makes up a significant proportion of muscle protein and serves as an energy source during prolonged exertion. It also competes with tryptophan for transport to the brain and thereby indirectly affects the perception of fatigue.

Test requirementsFasting, at least 12 hours
Reference range150–320 µmol/l (depending on method)
Test intervalevery 3 to 6 months
MaterialEDTA plasma

Why is this level measured?

Valine completes the BCAA profile and helps assess recovery problems and overtraining.

High level

Elevated levels can result from high protein intake or supplements; persistently elevated BCAA levels are considered a sign of insulin resistance.

Low level

Low levels point to inadequate protein intake or high consumption during intensive training.

Frequently asked questions

Do BCAA supplements help?
Studies show little additional benefit when total protein intake is adequate. They may be useful when protein intake is demonstrably insufficient.

Related markers

Vitamin B12 is needed to produce red blood cells, build the myelin sheaths around nerves, and break down homocysteine. Significant amounts are found only in animal products. A transport factor from the stomach is needed for absorption in the small intestine - without it, a deficiency develops despite adequate intake.

Test requirementsNo special requirements
Reference range200–900 pg/ml
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

The liver stores B12 for years. A deficiency often goes unnoticed until later, when it can cause anemia as well as nerve and concentration problems that may persist if detected late.

High level

High levels are usually caused by supplements and are harmless. Very high levels without supplementation should be checked by a doctor.

Low level

At-risk groups include people who follow a vegan or very low-meat diet, older adults, people with stomach disorders, and users of acid blockers or metformin.

Frequently asked questions

Why can total B12 be normal despite a deficiency?
Much of the measured B12 is bound to a protein that does not deliver it to the cells. Active holo-transcobalamin is therefore a more meaningful measure.

Do vegans need to supplement B12?
Yes. Vitamin B12 is found in significant amounts only in animal-based foods – supplementation is considered necessary for a purely plant-based diet.

Zinc is a component of over 300 enzymes and numerous gene switches. It is needed for cell division and is therefore especially important wherever tissue renews rapidly: in the skin, hair, mucous membranes, and immune system. Testosterone production also depends on zinc. The body does not build up large stores, so a regular intake is necessary.

Test requirementsFasting, in the morning
Reference range11–20 µmol/l
Test intervalevery 3 to 6 months
SampleBlood serum

Why is this level measured?

A deficiency causes nonspecific symptoms such as frequent infections, poor wound healing, hair loss, brittle nails, skin problems, and impaired taste – symptoms that are rarely immediately linked to zinc.

High level

Elevated levels occur practically only as a result of high-dose supplements. A consistently high intake can inhibit copper absorption.

Low level

At-risk groups include people who follow a vegetarian or vegan diet, athletes, older adults, and people with chronic intestinal diseases.

Frequently asked questions

Why should zinc be measured while fasting?
Blood zinc levels fluctuate throughout the day and measurably decrease after eating. For comparable results, it is advisable to have the test done in the morning while fasting.

Does zinc interfere with copper absorption?
Yes, if intake is high over a long period. Anyone taking high doses of zinc for an extended period should also have their copper status monitored.

Related markers

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The content is for general information and does not replace medical advice, diagnosis, or treatment. Reference ranges depend on the laboratory, method, and age – the information on your test result is always authoritative.

Frequently asked questions

What should you know about blood test results?

What is the difference between a DNA, blood, and microbiome test?

A DNA test shows your genetic predisposition, a blood test your current status, and a microbiome test the composition of your gut flora. Your DNA never changes, blood values change over months, and your gut flora within weeks. The 67 biomarkers in this glossary all come from blood tests and show levels such as vitamins, minerals, and hormones at the time the sample was taken.

Where are mybody x's blood tests analyzed?

Analyzed in a laboratory in Germany certified to ISO 9001 and ISO 13485. Your data is processed in accordance with ISO 27001 and the GDPR. You collect the sample yourself as capillary blood from your fingertip; the laboratory measures the values and interprets them in the report. Reference ranges depend on the laboratory, method, and age—the information on your test result is always authoritative.

Who are mybody x blood tests suitable for?

The blood tests are intended for adults aged 18 and over who want to know their current levels, such as vitamins, minerals, or hormones. If you are pregnant or breastfeeding, have a blood clotting disorder, or take blood thinners, only take the test after consulting your doctor.

How does a blood test at mybody x work?

Analysis takes 3 to 5 business days from the time your sample arrives at the lab. Activate the kit at mylab.mybody-x.com, take a small blood sample from your fingertip at home, and drop it off at the post office the same day. It is analyzed at a specialist laboratory in Germany, and you can download your report as a PDF in the customer portal.

How is my health data protected?

Your data is processed in accordance with ISO 27001 and the GDPR, and transmitted using SSL encryption. Your sample is processed under a pseudonymous code, with the information linking it to you stored separately. Blood samples are destroyed two months after the analysis is completed. You can view your results in your customer portal at mylab.mybody-x.com.

How do I find out which test is right for me?

The test finder guides you to a test that matches your goal with just a few questions. The advice articles on nutrition, skin, gut, or the immune system help you put things into context before making a decision. If you’d rather talk to someone, book a free consultation about your question. In the glossary on this page, you can read in advance about what an individual result means.

Reference ranges depend on the laboratory, method, and age—the information on your test report is always authoritative. DNA analysis is intended for nutritional and lifestyle counseling. It is not a diagnostic procedure, does not predict disease, and does not replace a medical examination or consultation. Genetic variants describe probabilities across population groups, not certainties for individuals. The content is for general information and does not replace medical advice, diagnosis, or treatment.

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